Unveiling the Differential Impact of Clarithromycin and Metronidazole on the Incretin Effect of Sitagliptin

Background: Sitagliptin is a commonly used drug for the treatment of type 2 diabetes. Studies show that diabetic patients are at high risk suffering severe complications after amoebic infection. To treat these infections drugs like clarithromycin and metronidazole most indicated. Methods: were conducted in normal male Wistar rats with oral doses 10 mg/kg body weight sitagliptin, & 5 metronidazole, their combination duration 14 days. Blood glucose level was analyzed on weekly basis help glucometer. For measuring plasma insulin blood collected heart puncture ELISA. Result: The themselves do not have any hypoglycemic.However, when together it increases anti-diabetic effect sitagliptin. This means there drug-drug interaction between After evaluation liver drug-metabolizing enzyme, concluded inhibits CYP3A4 enzyme which responsible metabolism As result sitagliptin increases. However, use such interactions. Conclusion: From this study combined may need little dose adjustment care should be taken prescribed to patient. While has no significant therapy.